Cerebrospinal fluid analysis in dogs with neurological disease
Scientists evaluated the clinicopathologic differences between cerebrospinal fluid collected from the cerebellomedullary (CM) and lumbar cisterns in dogs presented for evaluation of neurologic disease.
Fifty-one client-owned dogs undergoing magnetic resonance imaging (MRI) and CSF collection for investigation of neurologic disease.
Cerebrospinal fluid was prospectively collected from the CM and lumbar cisterns in all patients. The total protein (TP) concentration, red blood cell (RBC) count, and total nucleated cell count (TNCC) were analyzed within 30 minutes of collection. Results and cytology findings were interpreted by a single pathologist.
Fifty‐one paired samples of cerebrospinal fluid were collected. The TNCC, RBC, and TP were different between collection sites.. The TNCC was significantly different in the cervical and thoracolumbar localizations but not for intracranial localizations. The pathologist's interpretation differed between sites in 66.7% of the cases.
In dogs with lesions that neurolocalized to the brain or cervical spinal cord, there may be clinical benefit in collecting fluid from both the CM and lumbar cisterns.
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