A study examined the records of eleven dogs with intestinal masses diagnosed as intestinal lymphoma with anaplastic morphology. Eight (62%) of the cases presented with intestinal perforation, and all cases had 1 or more masses arising from the small intestine. The study found:

• Histologically, all cases were characterized by transmural infiltrates of large, CD3-positive and frequently CD30-positive cells.

• Neoplastic T cells had marked anisocytosis and anisokaryosis, prominent nucleoli, and occasionally indented to reniform nuclei.

• There was abundant necrosis and inflammation with occasional vascular invasion within neoplastic masses.

• All cases had a monoclonal T-cell receptor γ gene rearrangement.

• The median survival time was 5 days, with 1 dog surviving 2 years after the initial diagnosis.

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Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs