Anesthetic effects of isoflurane and propofol on cerebrospinal fluid biomarkers in dogs
Nine dogs were anesthetized at two different periods, one month apart. In the first period, the dogs were intravenously anesthetized with propofol, and in the second period, the dogs received inhalant anesthesia with isoflurane. In both cases, CSF and blood were collected 15 minutes and 3 hours after induction and analyzed for lactate, pyruvate, glucose, creatine kinase, glutamate, and electrolyte concentrations.
CSF lactate (CSF-L) showed variation depending on the anesthetic agent and time, being significantly lower after 3 hours of anesthesia in the propofolgroup and showing a trend to increase over time in the Isofluranegroup. No changes were detected over time or between groups in CSF glutamate, glucose, or electrolytes.
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