Evaluation of Protamine Zinc Insulin Treatment in Cats

A study evaluated the outcome of cats with diabetes mellitus treated with protamine zinc insulin. Researchers evaluated 185 client-owned domestic cats. Patient records were used to examine factors suspected of influencing success of diabetes management. The remission probability was 56.2%. Survival time had a median of 1488 days. Recent pre-diabetic corticosteroid use, lower mean blood glucose concentration during treatment, and lower mean insulin dose was associated with the likelihood of remission. A low-carbohydrate diet, occurrence of remission, lack of diabetic ketoacidosis at diagnosis, lower mean blood glucose value during treatment, and lower blood glucose value at diagnosis were associated with increased survival time.

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Loose-control of diabetes mellitus with protamine zinc insulin in cats: 185 cases (2005-2015).