Postmortem Evaluation of Renal Tubular Vacuolization in Critically Ill Dogs

A study evaluated fifty-three critically ill dogs for the frequency of renal tubular vacuolization. Renal tubular vacuolization (RVT) was noted in 45 (85%) of 53 critically ill dogs and was most commonly located to the medullary rays (68%). Cumulative 6% hydroxyethyl starch (HES) dose  and presenting serum creatinine concentration were significant predictors of RTV severity. For every 1 mL/kg increase in 6% HES dose that a dog received, there was 1.6% increased chance of having more severe RTV. In addition, for every 88.4 μmol/L (1 mg/dL) increase in presenting serum creatinine, there was a 22.7% increased chance of having more severe RTV.

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Postmortem evaluation of renal tubular vacuolization in critically ill dogs