African Horse Sickness (AHS)is an arthropod-borne viral disease of equids with a mortality rate up to 95%. The virus is considered endemic to the equatorial, eastern, and southern regions of Africa.

Researchers sought to create an alternative safe and effective vaccine using plant-based expression systems.

The study showed that AHS virus proteins in plants not only allowed for the assembly of homogenous AHS virus virus-like particles (VLP), but also single, double and triple chimeric VLPs.

Plant produced chimeric AHSV-6 VLPs were found to be safe for administration into 6 month old foals as well as capable of eliciting a weak neutralizing humoral immune response in these target animals.

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Plant-produced chimeric virus-like particles - a new generation vaccine against African horse sickness.