A study evaluated the ocular surface microbiome of healthy cats following topical antibiotic use. Twenty-four eyes from twelve adult, research-bred, female spayed domestic shorthaired cats were evaluated.

Erythromycin ophthalmic ointment (0.5%) was applied to the ocular surface of one eye of a cat three times daily for 7 days, while the fellow eye served as an untreated control.

The most common bacteria identified were Proteobacteria (42.4%), Firmicutes (30.0%), Actinobacteria (15.6%), and Bacteroidetes (8.1%). The most abundant bacterial families sequenced were Corynebacteriaceae (7.8%), Helicobacteraceae (7.5%), Moraxellaceae (6.1%), and Comamonadaceae (5.6%).

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Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin.