Babesiosis is a widespread disease that affects both humans and animals, including dogs. It is caused by tiny parasites that live inside red blood cells. Among these parasites, Babesia rossi is particularly dangerous for dogs and can cause severe symptoms. The disease can vary in its presentation, ranging from mild and unnoticed to severe and potentially fatal.

This study aimed to compare the blood protein profiles of dogs with babesiosis and healthy dogs. A total of 32 dogs infected with Babesia rossi were included, with 18 having uncomplicated cases and 14 experiencing complicated cases of the disease. Additionally, 20 healthy dogs were also part of the study.

The researchers found significant differences in the abundance of 78 proteins among the three groups of dogs. By analyzing these proteins and the related pathways, they discovered important variances in processes such as blood clotting, the immune system's initial response, lipid metabolism, and inflammation. This information is valuable in understanding how dogs react to Babesia rossi infection and may contribute to the development of new treatment approaches.

The study's use of a proteomic profiling technique allowed for the identification of potential biomarkers in the dogs' blood, which could help differentiate between mild and severe cases of babesiosis caused by Babesia rossi. These findings have implications for studying the interaction between the host (dogs) and the parasite, as well as for the exploration of new therapeutic targets.

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https://www.nature.com/articles/s41598-023-37312-9