A groundbreaking study has shed new light on the gene expression profile and cellular origins of canine peripheral T-cell lymphoma (PTCL), offering promising insights for both veterinary and human medicine. PTCL, a diverse group of T-cell cancers notorious for poor treatment responses, finds a parallel in the most common human subtype, PTCL-not otherwise specified (PTCL-NOS). This similarity has spurred interest in canine PTCL as a potential model for human PTCL research.