High-Intensity Zones in Dogs with Lumbosacral Intervertebral Disc Degeneration: Insights from MRI and Histopathological Findings
Diagnosing and managing lumbosacral pain in dogs remains a clinical challenge, necessitating comprehensive diagnostic approaches. Magnetic resonance imaging (MRI) plays a pivotal role in identifying structural abnormalities associated with intervertebral disc (IVD) degeneration. This retrospective study explores the presence of high-intensity zones (HIZ) in the dorsal annulus fibrosus (AF) of the lumbosacral region in dogs, correlating MRI findings with histopathological features.
Methods
The study evaluated T2-weighted (T2W) and T1-weighted (T1W) sagittal MRI scans from dogs with IVD degeneration, using a classification system adapted from human medicine to characterize HIZ. Among 836 dogs with IVD degeneration, 57 (6.8%) exhibited T2W HIZ. The median age of affected dogs was 7 years, with a median weight of 33.7 kg. All cases with HIZ showed radiological evidence of degenerative lumbosacral stenosis.
Key Findings
MRI Characteristics:
The most common HIZ shape on T2W imaging was round (43%).
14% of lesions also appeared hyperintense on T1W imaging.
Histopathological Analysis:
Examination of 11 dorsal AF samples collected during decompressive surgery revealed two distinct patterns:
Reactive cystic structures (3/11 cases)
Granulation tissue (8/11 cases)
These patterns exhibited differential MRI presentations, suggesting varied underlying pathological processes.
Significance of the Study
This is the first study to document HIZ in the lumbosacral region of dogs with IVD degeneration. The findings highlight the potential diagnostic value of HIZ in identifying annular pathology. However, further prospective studies are needed to determine the clinical relevance and prognostic significance of these lesions in relation to pain and functional outcomes.
The presence of HIZ in dogs with lumbosacral IVD degeneration provides new insights into the structural changes associated with disc disease. Recognizing these MRI features may enhance diagnostic accuracy, though future research should focus on correlating imaging findings with clinical symptoms to better guide treatment strategies.
Real full article here: High-intensity zones in dogs with lumbosacral intervertebral disc degeneration: insights from MRI and histopathological findings
