The safety and stability of anesthesia in veterinary surgeries are crucial, especially when it comes to managing cardiovascular and respiratory changes in dogs. A recent study aimed to assess the effects of two different anesthesia protocols on the heart health of female dogs undergoing elective ovariohysterectomy. Specifically, the researchers compared dexmedetomidine (GDEX) and midazolam-ketamine (GMID) combinations in 28 female dogs, evaluating their cardiovascular response through echocardiographic indices at various stages of anesthesia.

The study divided the dogs into two groups, with each receiving one of the drug combinations. The key findings included notable variations in heart rate, stroke volume, and cardiac output between the groups. While heart rate was higher in the GMID group, rectal temperature was significantly lower at the end of surgery compared to the GDEX group. Both anesthetic protocols led to a decrease in ejection fraction and fractional shortening, but the GMID combination showed a quicker recovery of these values post-surgery.

Notably, the GMID group exhibited more stable systolic function and cardiovascular parameters, suggesting that midazolam combined with ketamine offers better cardiac stability than the dexmedetomidine-based protocol. This makes GMID a promising choice for achieving hemodynamic and respiratory stability during canine surgery.

In conclusion, the study highlights that while both anesthetic combinations are effective, GMID is more cardio-stable, making it the preferable option for surgeries where cardiovascular health is a primary concern.

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