Breed-specific evaluation of serum biochemical markers in canine hip dysplasia

Canine hip dysplasia (CHD) remains a significant concern globally, warranting improved diagnostic strategies. This study delves into the potential of serum biochemical markers to differentiate between healthy Tornjak dogs and those with hip dysplasia, aiming for a breed-specific approach.

Study Details:

• Participants: 99 Tornjak dogs were categorized based on radiographic findings: 51 with no signs of CHD and 48 with mild to severe CHD.

• Methods: Serum levels and enzyme activity of hyaluronic acid (HA), procollagen II C-terminal propeptide (PIICP), and metalloproteinase 9 (MMP9) were compared between the two groups using statistical analyses.

• Results: Dogs with CHD showed lower HA levels and higher levels of PIICP and MMP9 activity compared to healthy dogs, with significant differences noted. These markers exhibited high sensitivity and specificity in distinguishing between the two groups.

Clinical Implications:

• The study suggests that serum levels of HA, PIICP, and MMP9 activity could serve as effective diagnostic markers for CHD in Tornjak dogs.

• Breed-specific studies like this provide valuable insights for veterinarians and breeders, aiding in early detection and informed breeding decisions.

• Understanding the biochemical profile of CHD enhances our ability to manage and mitigate the impact of this orthopedic condition in dogs.

This pioneering research underscores the potential of serum biochemical markers in diagnosing CHD in Tornjak dogs. By leveraging these markers, veterinarians can enhance their diagnostic toolkit, ultimately improving the health and welfare of affected animals. Read the full article here: Breed-specific evaluation of serum biochemical markers in canine hip dysplasia observed in a Tornjak dog population