Researchers evaluated the speed and extent of in vitro killing of canine urinary tract infection pathogens by ampicillin, cephalexin, marbofloxacin, pradofloxacin, and trimethoprim/sulfamethoxazole.

Results showed that marbofloxacin and pradofloxacin killed more bacterial cells, and faster than other agents. Significant differences were seen between drugs for killing Escherichia coli, Proteus mirabilis, Enterococcus faecalis, and Staphylococcus pseudintermedius strains. At the maximum urine drug concentrations, significantly more E. coli cells were killed by marbofloxacin than by ampicillin , cephalexin, and TMP/SMX and by pradofloxacin than by cephalexin and TMP/SMX.

The goal of this research is for practitioners to consider drug selection for short course therapy in uncomplicated urinary tract infections in dogs.

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In Vitro Killing of Canine Urinary Tract Infection Pathogens by Ampicillin, Cephalexin, Marbofloxacin, Pradofloxacin, and Trimethoprim/Sulfamethoxazole