Researchers evaluated the use of mycophenolate mofetil (MUE) and glucocorticoids to treat dogs with meningoencephalomyelitis of unknown etiology (MUE). Medical records of eighty-six client owned dogs with meningoencephalomyelitis that had been treated with prednisolone and MMF were evaluated.  

A partial or complete response to treatment was recorded for 75 dogs. The median survival time was 558 days. Dogs that showed clinical response with no relapse over the treatment period  had significantly longer median survival times.

 A significantly higher mortality rate found in dogs that did not have complete response to treatment. 

 Adverse effects included gastrointestinal upsets in 26 dogs (30.23%), sporadic infections in 17 dogs (19.77%), and pancreatitis in seven dogs (8.14%).

The study suggest that adjunctive MMF treatment for MUE is safe and comparable to other protocols.  

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Mycophenolate and prednisolone treatment for dogs with meningoencephalomyelitis