A new, 10-year study by researchers at the University of California, Davis, examined 35 dog breeds and found vulnerability from neutering varies greatly depending on the breed. The study was published in the journal Frontiers in Veterinary Science.

“There is a huge disparity among different breeds,” said lead author Benjamin Hart, distinguished professor emeritus at the UC Davis School of Veterinary Medicine. Hart said there is no “one size fits all” when it comes to health risks and the age at which a dog is neutered. “Some breeds developed problems, others didn’t. Some may have developed joint disorders but not cancer or the other way around.”

Researchers analyzed 15 years of data from thousands of dogs examined each year at the UC Davis Veterinary Medical Teaching Hospital to try to understand whether neutering, the age of neutering, or differences in sex when neutered affect certain cancers and joint disorders across breeds. The joint disorders examined include hip dysplasia, cranial cruciate ligament tears and elbow dysplasia. Cancers examined include lymphoma; hemangiosarcoma, or cancer of the blood vessel walls; mast cell tumors; and osteosarcoma, or bone cancer.

In most breeds examined, the risk of developing problems was not affected by age of neutering.

Breed differences by size and sex

Researchers found that vulnerability to joint disorders was related to body size.

“The smaller breeds don’t have these problems, while a majority of the larger breeds tend to have joint disorders,” said co-author Lynette Hart, professor at the UC Davis School of Veterinary Medicine.

One of the surprising exceptions to this was among the two giant breeds — great Danes and Irish wolfhounds — which showed no increased risk to joint disorders when neutered at any age.

Researchers also found the occurrence of cancers in smaller dogs was low, whether neutered or kept intact. In two breeds of smaller dogs, the Boston terrier and the shih tzu, there was a significant increase in cancers with neutering.

Another important finding was that the sex of the dog sometimes made a difference in health risks when neutered. Female Boston terriers neutered at the standard six months of age, for example, had no increased risk of joint disorders or cancers compared with intact dogs, but male Boston terriers neutered before a year of age had significantly increased risks.

Previous studies have found that neutering or spaying female golden retrievers at any age increases the risk of one or more of the cancers from 5 percent to up to 15 percent.