How does single-dose CBD effect dogs and cats?
The use of cannabidiol (CBD)-rich hemp products is becoming popular among pet owners with no long-term safety data related to consumption in adult dogs and cats. The purpose of this study was to determine the single-dose oral pharmacokinetics of CBD, and to provide a first look into assessing the safety and adverse effects during twelve-week administration using a hemp-based product in healthy dogs and cats.
Related: Get our guide to CBD
Eight of each species were provided a 2 mg/kg total CBD concentration orally, twice a day, for twelve weeks with screening of the single-dose pharmacokinetics in six of each species. Pharmacokinetics revealed a mean maximum concentration (Cmax) of 301 ng/mL and 43 ng/mL, area under the curve (AUC) of 1297 ng-h/mL and 164 ng-h/mL, and time to maximal concentration (Tmax) of 1.4 hours and 2 hours, for dogs and cats, respectively.
Serum chemistry and complete blood count results showed no clinically significant alterations, however one cat showed a persistent rise in alanine aminotransferase (ALT) above the reference range for the duration of the trial. In healthy dogs and cats, an oral CBD-rich hemp supplement administered every twelve hours was not detrimental based on CBC or biochemistry values. Cats do appear to absorb or eliminate CBD differently than dogs, showing lower serum concentrations and adverse effects of excessive licking and head-shaking during oil administration.
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