A study evaluated the single-dose oral pharmacokinetics of cannabidiol and the safety profile of  12-week administration in healthy dogs and cats. Eight of each species were given a 2 mg/kg total CBD concentration orally twice daily for 12 weeks.

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The study suggests that cats may absorb or eliminate cannabidiol differently than dogs, showing lower serum concentrations.  Pharmacokinetics revealed a mean maximum concentration of 301 ng/mL and 43 ng/mL with time to maximal concentration of 1.4 h and 2 h, for dogs and cats, respectively.

Serum chemistry and CBC results showed no significant findings in 15 animals.   One cat showed a persistent rise in alanine aminotransferase (ALT) above the reference range for the duration of the trial. Cats in the study showed signs of excessive licking and head-shaking during administration.

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Single-dose safety assessment of cannabidiol in dogs and cats