Pharmacokinetics of a cannabinoid-based therapy for canine disorders.
A phytocannabinoid-based medicine that is currently marketed for the treatment of spasticity and pain in multiple sclerosis patients in Spain was evaluated in dogs.
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Researchers administered the product sublingually to Beagle dogs. In one group, dogs received 3 sprays total and blood samples were collected at 12 intervals up to 24 h later. In another group, the dogs received 3 sprays daily for 14 days, and blood samples were collected for 24 h post final dose.
Maximal plasma concentrations of both Δ9-THC (Cmax = 18.5 ng/mL) and CBD (Cmax = 10.5 ng/mL) were achieved 2 h after administration in the single dose condition and at 1 h in the multiple dose treatment (Δ9-THC: Cmax = 24.5 ng/mL; CBD: Cmax = 15.2 ng/mL).
11hydroxy-Δ9-THC was almost undetected. A potential progressive accumulation of both CBD and Δ9-THC was detected following repeated exposure.
No changes were observed regarding any of the dog’s neurological status, body temperature, respiratory rate and hemodynamic parameters.
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Pharmacokinetics of a cannabinoid-based therapy for canine disorders.