Effects of anthelmintics on the fecal microbiome of healthy dogs
Researchers evaluated the effect of anthelmintic administration on the fecal microbiome of dogs with and without subclinical Giardia species and Cryptosporidium canis infections.
Six healthy adult research beagles with subclinical giardiasis and cryptosporidiosis were administered a commercially available preparation of febantel combined with pyrantel and praziquantel (FPP) orally daily for three days. In addition nineteen healthy staff-owned dogs without giardiasis or cryptosporidiosis were divided into two treatment groups. One group of nine were administered fenbendazole orally daily for five days and the second group of ten did not receive treatment.
Feces were collected at multiple time points before and after anthelmintic administration. Fecal DNA was extracted for Illumina sequencing of the bacterial 16S rRNA gene and qPCR assays.
The study showed that neither febantel combined with pyrantel and praziquantel nor fenbendazole treatment caused a significant change in alpha or beta diversity or the relative abundance of bacterial species.
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