Analysis of cerebrospinal fluid (CSF) lactate concentrations in dogs with seizure disorders

Cerebrospinal fluid (CSF) lactate concentration can be useful as a biomarker of neurological diseases. Several studies have suggested that CSF lactate concentration increases in humans after a seizure. But, it’s unknown the association between seizure activity and increased CSF lactate concentration.

In a recent study, cerebrospinal fluid lactate concentration was collected from dogs that were referred for epileptic seizures. It was determined using a commercially available lactate monitor.

The results showed higher CSF lactate concentrations in dogs with focal seizures in dogs with generalized seizures. However, there was no change in lactate concentrations in dogs having single seizures, cluster seizures, or status epilepticus at different time points after the last seizure activity or dogs having different numbers of seizures within the previous three days. Dogs with inflammatory and neoplastic disease showed a greater concentration of CSF lactate than dogs with epilepsy.

The concentration of cerebrospinal fluid lactate was slightly affected by seizure activity in dogs. The study confirmed that higher concentrations of CSF are more dependent on the underlying disease process compared to seizure disorders.

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Cerebrospinal fluid lactate concentrations in dogs with seizure disorders