Patients included in the study were assigned to receive either a standard treatment protocol comprising IV/rectal diazepam and IV phenobarbital q8h (control group) or a standard treatment protocol in association with a single dose of 40 mg/kg levetiracetam rectally (rectal LEV group). Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders.

Twenty-one dogs were assigned to the rectal LEV group, and 36 to control group. The response rate was 94% in the rectal LEV group and 48% in the control group.

Study results suggest that rectally administered LEV combined with a standard treatment protocol provided good control of seizure activity in patients with cluster seizures.

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Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures.