Photon radiation therapy for cutaneous epitheliotropic lymphoma
Researchers evaluated total skin electron beam radiation therapy (TSEBT), which is an effective treatment for primary diffuse cutaneous lymphomas in humans, in a dog. W
The study case involved a 13.5 year old Bichon Frise with diffuse cutaneous epitheliotropic lymphoma that had failed medical management. Twenty-seven gray were delivered to the patient. A partial response was noticeable after four fractions and the tumor completely regressed progressively over the entire treated area by the end of therapy.
Adverse effects noted following treatment included lethargy, fatigue, weight loss, and oral mucositis and grade 2 alopecia, nail/claw changes, pruritus, scaling, anorexia, and diarrhea. Additionally, thrombocytopenia developed after fraction eight requiring a treatment interruption and modification prior to treatment continuation.
From the beginning of photon therapy until the time of the patient was euthanized because of an unrelated condition, only one new lesion on the head was identified and confirmed by histopathology within the treated fields.
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